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3-C (Cefixime) is a third-generation, orally administered cephalosporin antibiotic effective against a broad spectrum of Gram-positive and Gram-negative bacteria. It’s indicated for the treatment of infections such as:
- Upper Respiratory Tract Infections: e.g., otitis media, especially when other antibiotics are ineffective.
- Lower Respiratory Tract Infections: e.g., bronchitis.
- Urinary Tract Infections: including cystitis and pyelonephritis, where it has proven efficacy against common pathogens (e.g., Streptococcus pneumoniae, E. coli, Klebsiella, and H. influenzae).
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✅ Description:
Cefixime kills bacteria by disrupting their cell wall synthesis, and it remains effective in the presence of beta-lactamase enzymes, making it useful against penicillin-resistant bacteria. About 40%-50% of the drug is absorbed, regardless of food intake.
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✔️ Dosage & Administration
- Adults and children over 10 years: 200-400 mg daily, either as a single or divided dose.
- Children: 8 mg/kg/day, divided as needed. Dose adjustments are based on age and weight.
- Elderly: Same as adult dosage but with renal function monitoring.
- Renal Impairment: For creatinine clearance <20 ml/min, limit to 200 mg once daily.
✔️ Contraindications & Precautions
- Not suitable for patients with cephalosporin hypersensitivity. Caution is advised for penicillin-sensitive patients due to partial cross-allergenicity.
- Pregnant or nursing women should only use Cefixime if necessary.
- Avoid in infants under 6 months, as efficacy and safety are unverified.
✔️ Side Effects
Most side effects are mild, such as gastrointestinal issues (e.g., diarrhea, nausea) and hypersensitivity reactions (e.g., rash, urticaria). Rare cases may include pseudomembranous colitis and hematological changes.
✔️ Storage
Store below 30ºC, away from light and moisture, and out of children’s reach.
